I wrote in my last post that skepticism may be rooted in a desire to avoid tragedy, to the extent that tragedy is the product of stubbornly insisting on the universality and rightness (and righteousness) of what turns out always to be a partial and flawed view of the world.
There is a problem with the desire to avoid tragedy, of course: the easiest way to do it is to just not give a damn about anything. Historically, perhaps stereotypically, skepticism has always seemed to slide into quietism, complete passivity and indifference in the face of whatever happens. How do you know it matters, anyway?